Mouse Estrus Detector by ELMI Uses a simple yet clever method to tell when a female mouse is ready to reproduce (a phase called estrus).   Why the device is needed:

• Female mice go through different phases in their reproductive cycle, and knowing when they are in the estrus phase is important for breeding, experiments, and minimising the number of animals needed for research.
• Current methods, like checking vaginal cells under a microscope, are slow and stressful for the mice.

How the device works:

• Tiny Probe: The device has a small, smooth probe that is gently inserted into the mouse’s vagina.
• Electric Resistance Measurement: The probe sends a tiny electric signal that’s too weak to harm the mouse but strong enough to measure the resistance of the tissue inside the vagina. The resistance changes depending on what stage of the reproductive cycle the mouse is in.
• Estrus Detection: During estrus, the tissue has higher resistance compared to other phases. When the device measures resistance higher than a certain threshold (about 6 kΩ), it tells the researchers that the mouse is in estrus.

Why it’s better:

• Quick & Painless: The process takes only a second, doesn’t hurt the mouse, and doesn’t cause stress.
• Accurate: The device is more reliable and faster than older methods like visual checks or lab tests of blood and urine.

Practical Benefits:

• It allows scientists to better time breeding or experiments, which helps reduce the number of animals needed. Plus, it aligns with the 3Rs principle: Replacement, Reduction, and Refinement of animal use in research.

In summary, the MEDPro™ is a fast, accurate, and animal-friendly tool that uses electrical signals to detect when a mouse is ready to breed, improving research practices and animal welfare.

Articles and publications:

1. International Journal for Molecular Science Advancing 3Rs: The Mouse Estrus Detector (MED) as a Low-Stress, Painless, and Efficient Tool for Estrus Determination in Mice
2. Laboratory Animals for Science Inctrumental Method For Determining The Estrous Cycle Stages In Small Laboratory Rodents